Not recommended to initiate therapy in patients whom cataract or glaucoma surgery is scheduled. Allergic reaction in patients w/ history of sulfonamide allergy. Syncope. Intraoperative floppy iris syndrome during cataract & glaucoma surgery. Sit or lie down at 1st signs of orthostatic hypotension eg, dizziness, weakness. Perform digital rectal exam & determine PSA before treatment & at regular intervals afterwards. Not to be given in combination w/ strong CYP3A4 inhibitors in patients w/ poor CYP2D6 phenotype metaboliser. Concomitant use w/ strong & moderate CYP3A4 inhibitors. May affect ability to drive & use machines. Severe renal impairment (CrCl <10 mL/min). Not to be used by women. Childn.
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